An 85K SNP Array Uncovers Inbreeding and Cryptic Relatedness in an Antarctic Fur Seal Breeding Colony

first_imgHigh density single nucleotide polymorphism (SNP) arrays allow large numbers of individuals to be rapidly and cost-effectively genotyped at large numbers of genetic markers. However, despite being widely used in studies of humans and domesticated plants and animals, SNP arrays are lacking for most wild organisms. We developed a custom 85K Affymetrix Axiom array for an intensively studied pinniped, the Antarctic fur seal (Arctocephalus gazella). SNPs were discovered from a combination of genomic and transcriptomic resources and filtered according to strict criteria. Out of a total of 85,359 SNPs tiled on the array, 75,601 (88.6%) successfully converted and were polymorphic in 270 animals from a breeding colony at Bird Island in South Georgia. Evidence was found for inbreeding, with three genomic inbreeding coefficients being strongly intercorrelated and the proportion of the genome in runs of homozygosity being non-zero in all individuals. Furthermore, analysis of genomic relatedness coefficients identified previously unknown first-degree relatives and multiple second-degree relatives among a sample of ostensibly unrelated individuals. Such “cryptic relatedness” within fur seal breeding colonies may increase the likelihood of consanguineous matings and could therefore have implications for understanding fitness variation and mate choice. Finally, we demonstrate the cross-amplification potential of the array in three related pinniped species. Overall, our SNP array will facilitate future studies of Antarctic fur seals and has the potential to serve as a more general resource for the wider pinniped research community.last_img read more

USS Nicholas Delivers More than Four Tons of Drugs to Mayport

first_img View post tag: Nicholas USS Nicholas Delivers More than Four Tons of Drugs to Mayport View post tag: Mayport View post tag: four View post tag: Navy View post tag: News by topic View post tag: than View post tag: Tons View post tag: Naval Back to overview,Home naval-today USS Nicholas Delivers More than Four Tons of Drugs to Mayport View post tag: Drugs View post tag: delivers July 18, 2012 View post tag: more Oliver Hazard Perry-class guided missile frigate USS Nicholas (FFG 47) delivered more than four tons of cocaine and marijuana to Naval Station Mayport, Fla., seized from drug interdictions conducted in support of Operation Martillo, July 17.Crew members offloaded approximately 3,408 kilograms (7,500 pounds) of cocaine, and 109 kilograms (239 pounds) of marijuana, with an estimated wholesale value of more than $93 million. The amount of cocaine seized was enough for 7.2 million doses, each dose approximately the same size as a sugar packet.USS Nicholas is returning to port after a 175-day deployment supporting counter illicit trafficking operations aimed at disrupting transnational organized crime and keeping drugs off the streets. “With the help of some partners in the region we accomplished what we set out to do; disrupt the drug trade,” said Cmdr. Stephen Fuller, USS Nicholas commanding officer. “Interdictions are challenging, but with the help of other naval units, U.S. Customs and Border Protection, and the partner nation navies, we executed a successful deployment.”During the deployment, Nicholas with embarked U.S. Coast Guard (USCG) Law Enforcement Detachment (LEDET) conducted a combination of six disruptions and interdictions while in the Caribbean Sea, and the Atlantic and Pacific coastal waters of South and Central America.Also during the deployment, Nicholas transited the Panama Canal twice, conducted passing exercises and an officer exchange with the Colombian Navy, certified 22 pilots through Helicopter Anti Submarine Squadron Light (HSL) 42 Detachment 9, four underway replenishments with a Chilean oiler, celebrated the anniversary of the War of 1812, and a “Crossing the Line” ceremony when the ship crossed the equator.U.S. Navy and Coast Guard vessels, U.S. military and patrol aircraft from the U.S. Customs and Border Protection agency, along with the support of allied and partner nation (PN) forces assisted with patrolling coastal regions from Colombia to Mexico to detect and monitor illicit traffic in order to cue and support PNs and U.S. interagency interdiction efforts.Patrol airplanes from Carrier Airborne Early Warning Squadron 77 (VAW-77), Patrol Squadron Eight (VP-8) operating from El Salvador and U.S. Customs and Border Protection long range patrol aircraft operating from Jacksonville, Fla. And Corpus Christi, Tex., use sophisticated sensors to detect suspicious vessels and coordinate interdictions by the U.S. Navy, Coast Guard and partner nations patrolling the region.More than 80 percent of the narcotics entering Central America and largely transiting through Mexico on their way to U.S. markets enter via maritime littoral routes, with the main conveyance being “go-fast” boats. By teaming up with regional partner nations and allied forces to scrutinize the littorals, transnational organized crime networks will be denied those routes.LEDETs belong to Tactical Law Enforcement Team South or Pacific Tactical Law Enforcement Team and are an armed deployable specialized force under the USCG’s Deployable Operations Group. They were created to support narcotics interdiction operations aboard U.S. Navy and allied ships and are capable of supporting DOD national defense operations. LEDETs provide specialized law enforcement capability and maritime security capabilities to enforce U.S. laws across a full spectrum of maritime response situations, maritime security augmentation and maritime interdiction anti-piracy operations.Operation Martillo (Spanish for ‘hammer’) is a U.S., European, and Western Hemisphere partner nation effort targeting illicit trafficking routes in coastal waters along the Central American isthmus. This joint service, interagency, and multinational operation is being led by Joint Interagency Task Force South, the agency charged with detection, monitoring, and supporting the interdiction of illicit trafficking in a 42 million square mile area under the direction of U.S. Southern Command (USSOUTHCOM).Operation Martillo is a component of the U.S. government’s coordinated interagency regional security strategy in support of the White House strategy to combat transnational organized crime and the U.S. Central America Regional Security Initiative.U.S. Naval Forces Southern Command and U.S. 4th Fleet (COMUSNAVSO/C4F) supports USSOUTHCOM joint and combined full-spectrum military operations by providing principally sea-based, forward presence to ensure freedom of maneuver in the maritime domain, to foster and sustain cooperative relationships with international partners and to fully exploit the sea as maneuver space in order to enhance regional security and promote peace, stability, and prosperity in the Caribbean, Central and South American regions.[mappress]Naval Today Staff, July 18, 2012; Image: US Navy View post tag: USS Share this articlelast_img read more

Oxford Mentor Scheme for Black Students

first_imgUS human rights activist Rev Jesse Jackson is heading up a campaign to encourage more black students to apply to Oxford.The project, which will be headed under the title of ‘Aspire’, is being pushed by Regent’s Park College, Canterbury Christ Church University and the Churches Together in Britain and Ireland (CTBI) racial justice team. The programme will focus on establishing and adding to mentoring schemes around Britain, in an attempt to identify problem areas faced by those thinking of applying to universities.Of the applications made to Oxford last year, only 151 of the applicants were black. Of that number, 26 were offered places. Myra Blythe, chaplain of Regent’s Park, said: “We are tapping into what is a nationwide issue but looking at it from the Oxford perspective.” “It is a major problem, not only in this country, but as Jessee Jackson is highlighting, in the United States too.”last_img read more

Indiana’s Absentee Voter Verification System Unconstitutional

first_imgIn addition, the lawsuit claims the state’s statutes regarding signature matching are being interpreted and applied “arbitrarily and inconsistently.” It noted about 45 absentee ballots were invalidated in Hamilton County because of signature mismatches while 13 were rejected in Madison County and none were discarded in either Boone or Porter counties.Indiana, the lawsuit argues, is violating the equal protection clause because voters are being disenfranchised by the haphazard application of the statutes.“Our votes are our voice in our government, yet this system has stripped far too many citizens of their right to choose their elected representatives,” Common Cause president Karen Hobert Flynn said. “This system is deeply flawed and we trust the court will side with the voters who were wrongly and unknowingly disenfranchised and end this unconstitutional and undemocratic system once and for all.”The case is Mary J. Frederick; John Justin Collier; William L. Marks, Jr.; Minnie Lee Clark; and Common Cause Indiana v. Connie Lawson, in her official capacity as Secretary of State; St. Joseph County Election Board; and M. Catherine Finello, Rita L. Glenn, and Murray Winn, each in their official and individual capacities as member of the St. Joseph County Election Board, 1:19-cv-1959.Plaintiffs are represented by William R. Groth and David T. Vlink of Fillenwarth Dennerline Groth & Towe, LLC, and Mark Sniderman of Findling Park Conyers Woody & Sniderman, PC. Common Cause Indiana and a group of registered voters in St. Joseph County are challenging the process Indiana uses to validate absentee ballots, calling it constitutionally flawed and asking a federal court to prohibit the state from rejecting absentee ballots based solely on perceived signature mismatches.The lawsuit, filed Thursday in the U.S. District Court for the Southern District of Indiana, highlights the method Indiana uses to review and authenticate ballots mailed in by absentee voters. Common Cause argues voters are being deprived of their due process and equal protection rights under the 14th Amendment because their ballots are being rejected without their knowledge and they are not being given an opportunity to challenge the decision.“Thousands of Indiana voters have had their ballots rejected by elections officials and those voters were never even notified that their votes were not counted,” said Julia Vaughn, policy director of Common Cause Indiana. “Some voters may well have had their ballots rejected for years under this faulty system, and state and county officials have never even bothered to tell those voters that they have been disenfranchised through this unfair and undemocratic system.”Secretary of State Connie Lawson’s office declined to comment on pending litigation. The St. Joseph County Election Board did not return a call requesting comment.The lawsuit pointed to St. Joseph County election officials who rejected 15 absentee ballots cast in the May 2018 Democratic Party primary for sheriff. A court-appointed recount commission concluded the ballots were improperly rejected and ordered them counted.In the Hoosier state, according to the lawsuit, absentee ballots must be verified by comparing the signature on the envelope containing the ballot with the signature on the application for the absentee ballot or “any other admittedly genuine signature of the voter.”If election officials determine the signatures do not match, the ballot will not be counted in the final election tally. Voters are not required to be notified of the rejection and are not given any opportunity to contest the finding.Moreover, Common Cause asserts the process of authenticating the signatures is “fraught with error and inconsistent application.” Indiana law does not contain any standards or criteria for determining whether a signature is genuine, and the state does not offer any training in handwriting analysisThe lawsuit argues Indiana’s “unilateral and unreviewable rejection of mail-in absentee ballots” violates the plaintiffs’ due process rights by depriving them and other similarly situated voters of their right to vote without due process of law. Marilyn Odendahl for www.theindianalawyer.comcenter_img FacebookTwitterCopy LinkEmailSharelast_img read more

MALEVOLENT OR INDIFFERENT

first_img MALEVOLENT OR INDIFFERENTGAVEL GAMUT By Jim RedwineFor thousands of years humans have pondered the same theological issues: Are there gods and, if so, are they benevolent, malevolent or indifferent towards humans? Of course, this debate can readily be applied to humans without reference to gods. How do we relate to one another? Are we generally good, bad or indifferent towards others?In my work, I have almost never encountered a purely evil person nor an unfailingly good one. My experience has been that most of us fall into neither category. Pretty much we just muddle through life somewhere between these extremes while generally behaving rather indifferently to much of what passes by.That basic human tendency is what leads us to put off until, maybe, later what we should address today. It is not a failure of conscience that results in inaction; it is simply more comfortable to ignore injustice than to address it, especially if it is a collective community injustice from long ago. Such is what has led us away from publicly recognizing the events of October and November 1878.No one alive bears any direct culpability for injustices done to Jim Good, Edward Warner, Jeff Hopkins, William Chambers, Daniel Harrison (Harris), Sr., Daniel Harrison, Jr. and John Harrison in Posey County, Indiana in 1878 by virtually the entire white power structure. But we can now begin to absolve our community of one hundred and forty years of injustice and indifference. In other words, we should not look to the gods for absolution, it is we who must deliver ourselves.Want to read other Gavel Gamut articles? Go to www.jamesmredwine.comOr “Like” us on Facebook at JPegRanchBooksandKnittingFacebookTwitterCopy LinkEmailSharelast_img read more

Café de Nata to open site in Camden Market

first_imgSource: Café de Nata“We are thrilled to be opening our latest Café De Nata site alongside the iconic Camden Market. Following continued success, it is the right opportunity for us to expand into an area with such a diverse culinary offering and strong following,” said Abdul Virji, co-founder of Café De Nata.“It takes time to select the right location, but the mix of independent operators, well-known London favourites and high street brands creates the ideal place from which we can grow our customer base.”Dumpling specialist Ugly Dumpling has also signed with LabTech, opening its second bricks and mortar site within Camden Market’s dedicated ‘Asian alley’.Its products combine both western ingredients, such as pecan pie and cheeseburgers, and Asian recipes to create what it describes as the ‘ultimate street snack and easy dining experience’.Maggie Milosavljevic, LabTech’s retail commercial director, added: “Over the past few weeks and months we have seen a steady increase in footfall, whilst adhering carefully to Covid-19 health measures, and so now is an opportune moment to be adding Café De Nata and Ugly Dumpling to our unique mix of food and beverage.”Their commitment is evidence of the enduring appeal and strength of Camden Market. We are confident both will be a hit with all our customers.” Source: Café de NataPortuguese tart specialist Café de Nata is to open a retail space in Camden Market in London as of mid-November.The firm signed with Camden Market owner LabTech to take a 600 sq ft space, which will have room for 12 covers as well as an open kitchen display where customers can see the tarts being made.Its Pastéis de Nata feature a flaky pastry filled with smooth custard which are then baked at a high temperature to give it a caramelised top. They come in seven variants: classic, strawberry, blueberry, raspberry, apple & cinnamon, coconut and chocolate.The treats have taken the UK by storm in recent years, as street food vendors, cake shops and even restaurant chain Nandos get in on the action.Café De Nata in Camden Market will also feature a large mural painted by an up and coming Portuguese artist, symbolising Portuguese culture, heritage and history. It joins the company’s other sites in Hammersmith, Soho and South Kensington.last_img read more

Aqueous Releases Killer In-Studio Performance Of “Strange Times” From Upcoming EP

first_imgBuffalo rising jam-stars Aqueous have released another awesome pro-shot video, as part of their recent weekly-release trend. After sharing videos of “Origami”, “Numbers and Facts”, and a cover of Radiohead‘s “Paranoid Android” from the same in-studio session, Aqueous have delivered a raging version of “Strange Times” that once again showcases their skills in the live setting. The band plans to release one more video next week, before releasing the whole session as a downloadable EP in the near future.Check out the video of “Strange Times” below, and enjoy the undeniable electric energy of Aqueous!Catch Aqueous and Mungion in New York City on 12/28 @ DROM for a Phish After-Party. Tickets available here.last_img read more

Michael Rabin to share in $1M prize

first_imgMichael O. Rabin of Harvard’s School of Engineering and Applied Sciences (SEAS) has been named a 2010 Dan David Prize laureate.Rabin will share the $1 million prize with Leonard Kleinrock, University of California, Los Angeles, and Gordon E. Moore, Woodside, Calif., who were also recognized in the “Future” category.The international prize covers three time dimensions — past, present, and future — that represent realms of human achievement. Past refers to fields that expand knowledge of former times; present recognizes achievements that shape and enrich society today; and future focuses on breakthroughs that hold great promise for improvement of the world. Three prizes of $1 million each are granted annually in the fields chosen for the three time dimensions.Rabin, the Thomas J. Watson Sr. Professor of Computer Science at the SEAS, was recognized for breakthroughs in the field of “Computers and Telecommunications.” Rabin was noted for his “major research results, which have had and which will continue to have a great impact on the shape of computer and communication technology and, in particular, for his work on automata and complexity theory, on probabilistic algorithms, and on ways to improve privacy and create unbreakable ways to encrypt data, making secrecy, privacy and protection ever more crucial to society,” according to the Dan David Prize announcement.To learn more about Rabin’s work, visit Rabin’s page on the Dan David Prize Web site.Other Dan David Prize laureates for 2010 include:Past — in the field of “March Towards Democracy”: Giorgio Napolitano, president of the Republic of Italy.Present — in the field of “Literature — Rendition of the 20th Century”: Amitav Ghosh, India/New York, for his novels, and Margaret Atwood, Toronto, for her versatile and prolific writing.Headquartered at Tel Aviv University, the prize is named after international businessman and philanthropist Dan David. The laureates, who donate 10 percent of their prize money toward 20 doctoral and postdoctoral scholarships, will be honored at a ceremony on May 9 at Tel Aviv University in the presence of Israeli President Shimon Peres.For more information, visit the Dan David Prize Web site.last_img read more

Failure, future and cooperative finance

first_imgby: William Azaroff and David KlavitterWhen we joined the Filene Research Institute’s prestigious i3 (Ideas, Innovation, Implementation) Group in late 2012, we were excited. That’s because we were invited to join a group of peers and colleagues from credit unions across North America to focus on innovating concepts, solutions and advancements in service of credit unions.And we didn’t mean to, but we started off by breaking some rules.In i3, we were meant to work in six month cycles. Within each cycle, participants must ideate, innovate and implement ideas and report back on to the rest of the i3ers and industry leaders about lessons learned and results. This method is pretty cool, especially because it forces i3ers to slow down and focus deeply on the idea portion of the process.In our i3 cohort, we started looking through that lens at how can we help our members’ overall well-being and reward and incentivize members based on a number of factors–that go way beyond the traditional thinking of consumer finance. We came up with the Credit Union Well-Being Incentive Program.Our hypothesis was that members who make good choices by living more responsibly–in terms of their environmental footprint, community activities and personal actions–are less risky, highly aligned and more loyal members who will become stronger advocates and more profitable over the long term.And according to the Filene Method, we totally failed. continue reading » ShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblrlast_img read more

US-Somalia to rebuild diplomatic relations

first_imgJohn Kerry with officials of the Somali government including the president The United States is expected to begin the process of reestablishing a diplomatic mission in Somalia after a more than 20 year break.This is according to the US secretary of State John Kerry who made a historic visit to Somalia.Western nations have poured aid into Somalia to help reconstruction and prevent it from sliding back into the hands of Al Shabaab.An African Union Force AMISON, supported by US drone strikes has pushed Al Shabaab from its former strongholds but it uses territory inside the country still under its control to launch attacks there and in Kenya and other neighboring countries.Kerry slo said that the US government will increase its support for support efforts made by the Horn of Africa country, following a brutal civil war which ravaged the country for over two decades, U.S Secretary of State John Kerry said on Tuesday.In a brief impromptu visit to Mogadishu, Kerry hailed Somalia for its resilience and determination to forge a peaceful country after emerging from a difficult past.“More than 20 years ago, the U.S. was forced to pull back from your country,” said Kerry, adding that now the “country is turning around.”“Now we are returning in collaboration with the international community and bearing high hopes but also mixed with ongoing concerns,” he added.The U.S. top diplomat expressed optimism about Somalia noting that the next time he visits the country he will be able to walk down the streets, an indication of improved security situation in Somalia.During his visit, Kerry held short discussions with Somali President Hassan Sheikh Mohamud, Prime Minister Abdirashid Ali Sharmake and civil society leaders where they discussed among other support for the Somali National Army and bolstering efforts on the fight against terror.Kerry also thanked the troops contributing countries to the African Union backed force, AMISOM, which include Kenya, Uganda, Burundi, Ethiopia and Sierra Leone.Kerry’s visit is billed one of a kind in U.S.-Somalia history as it is the first visit by a top American official to the Horn of Africa nation.State department said Washington will continue supporting the Somali National Army and the African Union backed force AMISOM in its efforts on fight against the militant group Al-Shabaab.The senior State Department also said once the U.S. embassy in Mogadishu is in fully operation, the U.S. will increase its presence in Somalia. At the moment the ambassador largely operates from Nairobi. Enditemlast_img read more