New Controversy Over Experimental IVF Method

first_imgA critique of potential in vitro fertilization (IVF) strategies to prevent babies from developing a common class of genetic diseases is sparking controversy. In today’s issue of Science, three evolutionary biologists argue that the ethical and scientific debates over an experimental IVF approach called mitochondrial replacement have underplayed some potential risks of the technique. While the trio support further development of the therapy, they say that more animal studies might be needed before clinical trials should proceed. But supporters of the technique—and a key IVF regulatory body in the United Kingdom—say that the concerns have already been taken into account and are minor compared with the symptoms the technique would prevent.Mitochondria are organelles that provide cells with energy. Replacing these powerhouses in egg cells has been proposed for women who carry mutations in their mitochondrial DNA (mtDNA) but still want to have a baby themselves. (Mitochondria carry their own DNA, which is inherited almost exclusively through the mother; although sperm have mitochondria, they degrade after fertilization of an egg.) Mutations in mtDNA can cause mitochondrial diseases, with a range of symptoms affecting the eyes, heart, brain, and other organs. Some cases are mild; others are fatal.Researchers have been working to develop ways that women who carry mtDNA mutations could have biological children without passing on the defect. Several methods are under development, but they all involve replacing the faulty mitochondria from a patient’s egg with those from a healthy donor. The techniques raise ethical concerns, because they involve altering the inheritable DNA of an embryo—“Three-parent babies” is often part of the headline that accompanies stories about the concept. In the United Kingdom, several ethical and scientific review panels have given the techniques a cautious endorsement, however, and the government has said that it wants to allow the technique. It is expected to release proposed regulations in the coming months, and the U.K. Parliament could vote on a final version next year. Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)A number of animal studies have shown that the technique can produce live offspring, and a study last year showed that it can produce normal-looking human embryos, at least through the blastocyst stage, about 5 days after fertilization. Some supporters of the technique have compared it to changing the battery in a camera.Klaus Reinhardt, an evolutionary ecologist at the University of Tübingen in Germany, and his co-authors contend that that analogy is too simple. They say animal studies suggest that the interactions between mtDNA and nuclear DNA are extensive, and minor changes in either one can affect mitochondrial function. Introducing donor mtDNA could lead to subtle problems in offspring that haven’t yet been studied in the only primate model for mitochondrial replacement: macaques. In mice and fruit flies, Reinhardt says, problems from swapping mitochondria show up disproportionately in males and often affect fertility. The published macaque studies on mitochondrial replacement follow the new offspring for 3 years, but males don’t reach adulthood until 4 years of age, Reinhardt notes.The U.K. Human Fertilisation and Embryology Authority (HFEA), which would be in charge of regulating the technique if it were allowed in the United Kingdom, says that its expert panel did take those concerns into account. The panel “carefully considered the interaction between nuclear and mitochondrial DNA and concluded that the evidence did not show cause for concern,” the agency says in a statement released today. The agency is talking with panel members to consider the issue of whether the macaques in the study were followed long enough, a spokesperson says.Developmental geneticist Robin Lovell-Badge of the MRC National Institute for Medical Research in London, who co-chaired the HFEA scientific review panel, says he doesn’t know of any evidence that interactions between mitochondrial and nuclear DNA could cause severe health problems in humans. If the therapy might lead to minor effects, “it is important that the family knows this risk,” he writes to ScienceInsider in an e-mail. However, he adds, “I suspect they would still choose [mitochondrial replacement] rather than have a very sick child.”Reinhardt says he agrees. “We are sure that HFEA will decide [whether to allow the therapy] on a case-by-case basis and will have safeguards. But couples that have mild mitochondrial disease might choose to wait 2 years until the macaques are a bit more mature.”last_img read more

South Africa’s de Villiers tops 9,000 ODI runs,South Africa’s de Villiers tops 9,000 ODI runs

first_img COMMENT South Africa’s AB de Villiers. File Photo – Reuters February 25, 2017 SHARE cricket India’s Sachin Tendulkar has the most ODI runs with 18,426 but averaged 44.83 with a strike rate of 86.23. × Published oncenter_img South Africa’s AB de Villiers. File Photo – Reuters SHARE SHARE EMAIL accomplishment South African AB de Villiers passed the 9,000-run milestone in one-day internationals in the third ODI against New Zealand in Wellington on Saturday.De Villiers is the 18th player and second South African behind Jacques Kallis to reach the 9,000 mark but has the highest average of 53.86 and is the only one of the leading scorers to have a strike-rate better than 100.India’s Sachin Tendulkar has the most ODI runs with 18,426 but averaged 44.83 with a strike rate of 86.23. De Villiers’ highest ODI score is an unbeaten 162 against the West Indies two years ago. 0 COMMENTSlast_img read more

Jose Mourinho says he won’t obsess about city rival Pep Guardiola

first_imgJose Mourinho won’t let his past rivalry with Pep Guardiola get in the way of his new career at Manchester United.With Guardiola taking charge at Manchester City, the pair will face off in the Premier League next season. They previously were adversaries when Mourinho was at Real Madrid and Guardiola at Barcelona.”I was with Pep in a league where the champion was either me or him, either Real Madrid or Barcelona,” Mourinho said Tuesday.”In that kind of situation, individual battles make more sense because they can affect the outcome (of the title race). If in the Premier League I were to focus on him and Manchester City, and he were to focus on me and Manchester United, someone else would be champion.”Mourinho, who was at Lisbon University to give a lecture, said he couldn’t speak about his new club but remarked that he wouldn’t be taking any player from Portugal to Old Trafford.last_img read more

India vs Australia: Why Kedar Jadhav is India’s lucky charm. A look at key stats

first_img India Today Web Desk HyderabadMarch 2, 2019UPDATED: March 3, 2019 08:55 IST India vs Australia: Kedar Jadhav was adjudged the man of the match for his star turn with bat and ball (AP Photo)HIGHLIGHTSKedar Jadhav took 1 wicket and then scored an unbeaten 81 to help India beat AustraliaIndia (240/4) beat Australia (236/7) by 6 wickets to take 1-0 lead in 5-match seriesIndia have won 80 per cent matches that Kedar has played and 85 when he bowls at least 4 oversBrief scores: India (240/4) beat Australia (236/7) by 6 wickets to take 1-0 lead in 5-match series. Jadhav (81*), Dhoni (59*), Kohli (44), Coulter-Nile (2/46) Full Scorecard | Highlights | Match ReportKedar Jadhav produced an all-round master class on Saturday to lead India to a 6-wicket win over Australia in the first one day international at the Rajiv Gandhi International Stadium in Hyderabad.Kedar starred with the bat, scoring an unbeaten 81, after taking one wicket from his 7 overs. Kedar and MS Dhoni put up an 141-run partnership for the fifth wicket to help the hosts take a 1-0 lead in the 5-match series.In fact, India have won 44 ODIs out of a total of 55 matches when Kedar has been a part of the playing XI, which is a 80 per cent win percentage – the highest for any player with 50 or more ODI appearances.In those matches, if Kedar bowls a minimum of 4 overs, then India’s win percentage rises to 85.71 per cent – with India winning 18 out of 21 games, one tied game and just 2 losses.100-run partnership between @JadhavKedar & @msdhoni #INDvAUS pic.twitter.com/AqYhv8U9QzBCCI (@BCCI) March 2, 2019″My bowling is all about reading batsmen’s mind. I tried to bowl stump-to-stump. I don’t think like I’m a bowler. I enjoy my responsibility,” Kedar said at the post presentation after being adjudged the player-of-the-match for his match-winning effort.A the start of the Indian chase of 236, Shikhar Dhawan was dismissed for a golden duck in the second over of their innings. Virat Kohli and Rohit Sharma though played with characteristic ease before Australia prized out three wickets with India’s total reading 99, to roar back into the match.advertisementKohli, who added 76 runs with Rohit, raced to a run-a-ball 44 before being foxed by an Adam Zampa delivery that beat his bat and rapped him on the pad.Rohit’s departure for 37 compounded India’s problems but Dhoni and Jadhav batted sensibly and did not panic even when the asking run rate climbed above six-an-over.But it was Dhoni who sealed the victory characteristically, with his sixth boundary off Marcus Stoinis. Both teams move to Nagpur for the second match of the series on Tuesday.Also Read | MS Dhoni overtakes Rohit Sharma for most sixes for India in ODIsAlso Read | Virat Kohli awestruck with Rohit Sharma’s unbelievable scoop shotFor sports news, updates, live scores and cricket fixtures, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for Sports news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Tags :Follow India vs AustraliaFollow Kedar JadhavFollow MS DhoniFollow 1st ODIFollow IND v AUSFollow Hyderabad India vs Australia: Why Kedar Jadhav is India’s lucky charm. A look at key statsBrief scores: India (240/4) beat Australia (236/7) by 6 wickets to take 1-0 lead in 5-match series. Jadhav (81*), Dhoni (59*), Kohli (44), Coulter-Nile (2/46). Kedar Jadhav scored an unbeaten 81 to lead India to a 6-wicket win over Australia in the 1st ODI.advertisementlast_img read more

New Community Home Opens in Cape Breton

first_imgSeven individuals with disabilities will get the support they need while living more independently with the opening of a community home in Port Hawkesbury, today, Oct. 29. Community-based homes provide necessary program and supports for people with disabilities while enhancing their ability to independently live, work and participate in their community. “This is a wonderful project as it was developed by the people of Port Hawkesbury,” said Community Minister Denise Peterson-Rafuse. “This new home will make life better for the residents and their families who will know their loved one is receiving the support they need while living as independently as they can.” The house, called Shalom or place of peace, will be home to five people who require some level of care and includes an apartment for two people who can live on their own with minimal support. “As I enter Shalom and see my daughter there, I feel a sense of great peace,” said Theresa Aucoin. “I watch in awe as these individuals, their families and the staff all come together to live, work, and grow into one big extended family who support and look after each other. What was once a dream is now a real home for my daughter and her new friends.” The $800,000 house was funded by the Department of Community Services and will be staffed and operated by the Regional Occupational Centre Society. “The opening of Shalom is a dream come true for the people in our area,” said Tom Gunn, society board chair. “We have been working hard to provide the services and supports that people with disabilities in our community need. We are grateful to all those who have worked so hard to make this dream become a reality for those people who now call Shalom their home.” The Services for Persons with Disabilities Program serves children, youth and adults with intellectual disabilities, long term mental illness and physical disabilities with community based services ranging from minimal support to residential living options. For more information go to www.gov.ns.ca/comslast_img read more

Security Council urges political solution to crisis in eastern DR Congo

The United Nations Security Council today urged key players to seek a political solution to the ongoing crisis in the eastern part of the Democratic Republic of the Congo (DRC), where insecurity has led to the displacement of some 700,000 people. In a statement read out by Ambassador Wang Guangya of China, which holds the Council’s rotating presidency this month, the 15-member body expressed its “deep concern at the deteriorating security situation in the east of the Democratic Republic of the Congo, in particular in North and South Kivu.” The Council also urged key players to “refrain from any action leading to a military confrontation, that could result in further tension and aggravate the ongoing humanitarian crisis in the Kivus, and to seek a solution to the current crisis through political and diplomatic means.” Ambassador Wang’s statement also called on the mixed brigades and their commanders to integrate into the Congolese armed forces and to stop recruiting activities. Today’s statement called on the Government to develop, in coordination with the UN Organization Mission in the DRC (MONUC), a plan to ensure security in the eastern part of the vast nation, including by promoting disarmament, demobilization and reintegration of Congolese and foreign combatants, as well as reconciliation, recovery and development. In addition, members of the Council emphasized the need to extend State authority throughout the region, and welcomed the intention of the Congolese authorities to facilitate an inclusive dialogue in the Kivus. Last week, the Council was briefed on the DRC by Under-Secretary-General for Peacekeeping Operations Jean-Marie Guéhenno, who said the concentration of Government forces and rebels led by General Nkunda in a “very volatile area where there are a number of unresolved issues” has resulted in a “very dangerous situation.” Mr. Guéhenno said the Congolese parties must “move away from the brink.” Responding to reporters’ questions, Mr. Guéhenno noted that Mr. Nkunda’s forces pose “the single most serious threat to the stabilization of the DRC at this stage.” 23 July 2007The United Nations Security Council today urged key players to seek a political solution to the ongoing crisis in the eastern part of the Democratic Republic of the Congo (DRC), where insecurity has led to the displacement of some 700,000 people. read more

Ottawas deficit shrinks as tax revenue grows

OTTAWA — The Canadian government ran a $941-million deficit for October compared with a $3.21-billion deficit in the same month last year.Ottawa’s fiscal monitor says the improvement came as revenue increased 11.1 per cent, boosted by higher personal income tax and Goods and Services Tax revenues.The results of a year ago included a one-time adjustment downward due to the introduction of the Conservative government’s income-splitting plan for families and a doubling of the children’s fitness tax credit.The newly elected Liberal government is planning to discontinue income splitting.Program spending for October 2015 increased by 0.4 per cent, while public debt charges fell 6.4 per cent.For the April to October period, the government posted a surplus of $634 million compared with a deficit of $3.95 billion in the same period a year earlier.Revenue for the first seven months of the fiscal year was up 8.7 per cent, while program spending was up 6.6 per cent. Public debt charges fell 3.6 per cent. read more

Afghanistan UN mission helps broker agreement between warring factions

The Mission reported today that both parties – led respectively by Karim Khan and Makdoum – are complying with the agreement, which calls for the safe handover of the bodies as well as the return of 11 prisoners taken captive during the clashes.Other provisions of the accord provide for complete demilitarization of the central bazaar and the installation of a neutral commander from a neighbouring district to control the area. All military groups were requested to stand down from their positions and remain in their respective villages.The agreement was successfully brokered following two days of talks with the parties by UNAMA and members of a security commission set up in May following an earlier agreement signed by the northern groups. read more

Niagara Symphony gets new conductor

After a year-long audition process, a musical leader has been chosen for Brock’s resident orchestra.Bradley ThachukBradley Thachuk will be music director and principal conductor for the 2011-12 season of the Niagara Symphony. He will be responsible for all artistic aspects of the symphony, including programming, guest artist selection and personnel. He is also responsible for revitalizing the symphony’s relationship with the community.“This outstanding orchestra has a distinguished past and huge potential,” Thachuk said. “I look forward to the challenge of exploring and expanding that potential as the Niagara Symphony becomes an even more vital part of the Niagara community.”The Toronto-born maestro is concluding a nine-year term as associate conductor of the Fort Wayne (Indiana) Philharmonic. He is the seventh music director and principal conductor in the Niagara Symphony’s 63-year history.Thachuk’s work has included:serving as music director of the Fort Wayne Youth Orchestraconducting for the Fort Wayne Balletrecent guest conducting engagements with the Richmond (Virginia) Symphony, the Windsor Symphony and the Reading (Pennsylvania) Symphonyserving in various positions with the Prince George Symphony Orchestra, the Cincinnati Symphony and Pops Orchestras, Miami University in Ohio and the Brampton Symphony Orchestraguest conducting in Slovakia, Switzerland, Italy and Portugal, as well as conducting the Hradec Kralove Philharmonic in the Czech RepublicThachuk will lead the Niagara Symphony in An Opening Celebration on Oct. 3.Link:• Niagara Symphony Orchestra read more

Former football coach convicted of sex attacks against young players

first_imgA former football coach George Ormond, who assisted in setting up the youth side of Newcastle United’s youth has been found guilty and convicted of sexually abusing young players for almost 25 years.Ormond was found guilty of 35 charges of indecent assault and one of indecency but was only cleared of one charge relating to an older Newcastle United player, according to Sky Sports.Ormond was remanded in custody and will be sentenced later this week since hasn’t given any visible reaction for his actions.“For over two decades, George Ormond abused young men and boys while working in the youth football scene in the North East of England,” Gary Buckley from the CPS said.Roberto Firmino, LiverpoolVirgil van Dijk praises Roberto Firmino after Liverpool’s win Andrew Smyth – September 14, 2019 Virgil van Dijk hailed team-mate Roberto Firmino after coming off the bench to inspire Liverpool to a 3-1 comeback win against Newcastle United.“To many of his victims he was a figure of authority, trust and influence.“Instead of nurturing and supporting them, he exploited his role to subject them to sexual abuse.”last_img read more

CBS Viacom to reunite in merger that creates roughly 30B company

first_imgStar Trek: Discovery is one of CBS’ flagship streaming series. CBS All Access CBS and Viacom, two television programming companies that split more than a decade ago, finalized a merger deal Tuesday to recombine, creating a single entity with about $30 billion in market value. The new company, which will be called ViacomCBS, brings brands like CBS and Showtime together with the likes of Nickelodeon, MTV, BET, Comedy Central and Paramount. A CBS-Viacom reunion is the latest in a wave of mergers and acquisitions of traditional media companies, as they try to come to grips with the scale of their emerging competitors in the tech world. Netflix and YouTube dominate eyeballs online, and companies like Apple and Amazon, with market caps hovering around $1 trillion, are delving more deeply into video programming. In response, legacy media companies are consolidating to bulk up. Following megadeals like AT&T buying Time Warner and Disney taking over Fox, CBS and Viacom become the latest to turn to M&A as they face a changing landscape where streaming’s on the rise and traditional pay-TV is slipping. (Disclosure: CBS Corp. is the parent of CNET.)During a call with analysts, executives said they hoped to bulk up CBS All Access with kids programming from Viacom, which owns Nickelodeon. Executives added that they continue to like the idea of pricing CBS All Access under $10 a month because they remain interested in driving up subscribers. One of the key motivations for combining, they said in a joint release, was streaming video. CBS and Viacom said a merged company would be in a better position to accelerate a “direct-to-consumer” strategy — industry jargon for streaming services that don’t involve any traditional TV distributor like a cable company. The companies collectively operate CBS All Access and Showtime’s streaming option, along with Pluto TV (a free streaming TV service in the US) and newcomers such as CBSN, ET Live and niche players like Noggin. They noted that the merger could give them opportunities to expand their streaming internationally. The companies also said their merger will improve opportunities in advertising and deals with distributors and create a stronger player to license their catalog to other platforms worldwide. The companies said they expect the deal, which still needs to win regulatory approval and clear other conditions, will close by the end of this year. Viacom shares will be converted into shares of CBS, with CBS shareholders owning about 61% of the combined company, and Viacom the rest.Viacom’s head, Bob Bakish, will lead the combined company as president and CEO, while CBS’s leader, Joe Ianniello, will serve as chairman and CEO of CBS proper. “Our unique ability to produce premium and popular content for global audiences at scale — for our own platforms and for our partners around the world — will enable us to maximize our business for today, while positioning us to lead for years to come,” Bakish said in a statement. Originally published August 13, 12:23 p.m. PT.Update, 2:25 p.m. PT: With comment from executives on call. Comments Tags TV and Movies Digital Media Share your voice 7 CBS Viacomlast_img read more

Laurie Schmidt New VP For Shell Alaska

first_imgShell Oil has replaced one of its top executives in charge of exploration off the coast of Alaska.Download AudioAs vice president of Shell’s Alaska venture, Pete Slaiby traveled the state to build support for Arctic drilling and defend the program against its critics.He left Anchorage almost two months ago for a new job at Shell’s corporate headquarters. That change wasn’t reported until last week, in the trade publication Petroleum News. Spokesperson Megan Baldino says it was announced internally at Shell – and is not related to problems the company faced during its last Arctic drilling season.“He led the venture for six years, extending well beyond the typical assignment,” Baldino said. “I don’t think anyone would argue that he leaves behind a legacy of leadership and working with communities and building partnerships. And that has positioned the venture for well into the future.”Baldino says an agreement between Shell and the Arctic Slope Regional Corporation to share in drilling proceeds is still going forward – even after Slaiby’s departure. For now, Shell is focused on securing legal permission to return to the Arctic this summer. And Laurie Schmidt is stepping in as the new vice president for Shell in Alaska. Schmidt is an attorney who’s been with Shell for 25 years. She has experience in internal auditing, overseeing contracting for drilling projects, and in community relations – both in Russia and in Nigeria.“So making sure that local people are trained and skilled to work on projects and can apply for and succeed in the jobs that are available anywhere where Shell works,” Schmidt said.Schmidt has already been sent to Barrow and Unalaska to meet with stakeholders since she took over February 1.last_img read more

Tunable quantum cascade laser

first_img Copyright 2010 PhysOrg.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed in whole or part without the express written permission of PhysOrg.com. More information: Kazuue Fujita, Tadataka Edamura, Shinichi Furuta, and Masamichi Yamanishi, “High-performance, homogenous broad-gain quantum cascade lasers based on dual-upper-state design,” Applied Physics Letters (2010). Available online: link.aip.org/link/APPLAB/v96/i24/p241107/s1 Explore further (PhysOrg.com) — One of the issues associated with lasers is their tunability. In many cases, if you want to produce a particular wavelength, you have to build a laser to accomplish this. In order to get another wavelength, you may have to build a different laser. A tunable laser would provide an opportunity to adjust the wavelength, without the use of another laser. One novel quantum cascade laser design that could achieve this is based on a dual upper state design. Citation: Tunable quantum cascade laser (2010, July 7) retrieved 18 August 2019 from https://phys.org/news/2010-07-tunable-quantum-cascade-laser.htmlcenter_img A team at the Central Research Laboratory at Hamamatsu Photonics K.K. in Japan has come up with, and tested, a tunable quantum cascade laser design that demonstrates broad optical gain. Their work is published in Applied Physics Letters: “High-performance, homogenous broad-gain quantum cascade lasers based on dual-upper-state design.”“Usually, quantum cascade laser designs have only one upper state, except for superlattice active region,” Kazuue Fujita, the lead author on the paper, tells PhysOrg.com in an email interview. In this case, though, there is an additional upper state added to the design of the laser. “The additional upper state is created by a first quantum well adjacent to the injection barrier. This state corresponds to a lowest energy state in the first quantum well.”Fujita goes on to explain that the regular upper state, seen in most conventional quantum cascade lasers, is designed to be nearly the same energy at operating condition as the state in the first quantum well. “Electrons are injected into the higher upper state via resonant tunneling from the previous injector. And then, electrons populated in the both upper states transit from both upper states to a lower state.” Both of these transitions contribute to optical gain.This new laser design would have a number of advantages over current quantum cascade laser designs insists Fujita. This laser design allows for broadband tuning. On top of that, there is weak dependence on voltage by these lasers, and they are not sensitive to temperature change. “Slow efficiency at threshold is observed to be nearly constant over the wide range. Also I-L characteristics show super-linear behavior. These distinctive features have never been observed in a quantum cascade laser so far,” Fujita explains. “I think this design concept holds large potentialities.”Fujita says that the design has actually been tested. “We have already fabricated and measured many lasers with the design. The lasers demonstrate very good performances. In addition, high temperature, continuous wave operation of the laser has also been achieved.”In terms of application, Fujita sees a great deal of usefulness, especially in terms of spectroscopy. Trace gas sensing is considered one of the more likely applications, since wide tunability is desired. “The external cavity quantum cascade laser with this design may operate very stable due to its low dependences on voltage and temperature,” he says. Due to its tunability, this quantum cascade laser design could also increase the cost efficiency of some applications. “This design can lead to high-performance broadband tuning. Therefore, the laser allows a reduction in the number of lasers in a spectroscopic analysis system.” Compact, wavelength-on-demand Quantum Cascade Laser chip created This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Uhoh Intel Globalfoundries to fastforward into 14nm

first_img Citation: Uh-oh, Intel. Globalfoundries to fast-forward into 14nm (2012, September 24) retrieved 18 August 2019 from https://phys.org/news/2012-09-uh-oh-intel-globalfoundries-fast-forward-14nm.html © 2012 Phys.org This is a nonplanar architecture optimized for low-power, mobile system-on-chip (SoC) designs. These chips will deliver a 40 percent to 60 percent improvement in battery life compared to two-dimension planar transistors at the 20nm node. Globalfoundries will go “3-D” in the use of three-dimensional “FinFET” transistors. The big deal about “FinFET” rests in its promoted superior low-power attributes. The FinFET architecture takes a traditional two-dimensional transistor design and turns the conductive channel on its side, resulting in a three-dimensional fin structure, surrounded by a gate controlling the flow of current. The 3-D transistor design operates at a lower voltage with minimal current leakage. This leads to a longer battery life for mobile applications and less power consumption for plugged-in applications. The power-consumption advantage could have important implications for networking chips in data centers.Intel’s challenge is not only in the rival company’s technology but also in 14nm timelines. Globalfoundries is speeding up its timeline for its 14nm process. Chip watchers note that in so doing it is playing leapfrog over other companies. The company will be ready to roll with a 14-nanometer process that will include its three-dimensional transistor architecture. This is said to be similar to Intel’s Tri-Gate method. Enthusiasts say that the 14nm-XM design is expected to carry performance and power benefits of three-dimensional FinFET transistors, possibly influencing a newer generation of mobile devices.With the Globalfoundries plan, chip designers will be able to start producing sample 14 nanometer chips in 2013. In 2014 or early 2015, the 14 nm chips will be part of the consumer marketplace. Technology development of the 14nm-XM has begun in Globalfoundries’ Fab 8, a fabrication plant in Saratoga County, New York. The company is making early process design kits (PDKs) which are available now. Customer tape-outs—the final result of the design—are expected in 2013. Globalfoundries was formerly a manufacturing arm of AMD. Headquartered in Milpitas, California, Globalfoundries now counts itself as one of the largest foundries in the world by revenue. Imec releases industry’s first 14nm process development kit More information: www.globalfoundries.com/technology/14XM.aspx Explore further (Phys.org)—Globalfoundries has made an announcement that amounts to a direct challenge to Intel, in the latter’s race to get further ahead in the mobile device ecosystem. Both Globalfoundries and Intel will be racing for a more dominant position with higher performing and power efficient systems for smartphones and other devices. In short, Globalfoundries announced Thursday that it is accelerating its technology roadmap. Its newest design achievement for the mobile market is in the form of 14nm chip technology. The company provided some details about its 14nm-XM (“extreme mobility”) process. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Lets pimp the disco

first_imgTell us a bit about yourselves and how did you guys come together as a band?We’ve both been individual musicians for awhile now prior to this collaboration. Saba has been singing with a bunch of other bands as well as working as a professional sessions vocalist and playback singer, and Imaad is the frontman/ guitarist for The Pulp Society, as well as produces solo under the moniker Madboy. Imaad heard Saba’s voice at a late night jam with some friends and immediately knew he had to get her to sing on some of his productions. Also Read – ‘Playing Jojo was emotionally exhausting’And how did the name come about?It’s basically a combination of two solo projects. Madboy is Imaad’s project as a solo producer and Mink is Saba’s moniker as a producer and DJ. So we just thought combining the two would be simple and non-pretentious. Tell us about what drives you guys, what are your influences?Our personal influences are extremely varied and diverse but for this project we are focusing on a sound which is driven by old style Harlem swing and bringing that into context with production that’s rooted in disco and funk. It’s our own trademark sound and it’s hard to explain too much- it’s something that needs to be experienced. Also Read – Leslie doing new comedy special with NetflixTell us a bit about the songs you have planned for this chapter at Raasta?We haven’t been releasing too much of our material online, because we like each of our releases to be really special and when the EP is released, It’s going to be pretty hyped. But in spite of that, a lot of our tunes have been spreading by word of mouth and gigs that have travelled all over the place. Our songs – Pimp the Disco, Taste your kiss, Lemonade (which was our first single release and is on Soundcloud) Trouble, Soulboy etc and many more will all be on the set list. What’s next in the pipeline for you guys?We play Sunburn in Goa which is the last gig for the year for us coming at the end of our first year as ‘Madboy/Mink’ and it’s been a very busy year in terms of gigs. We’re just going to take stock, lock ourselves in the studio for a little while, and complete the final mixes for our EP which will be out most probably by the end of Feb or beginning of March – and will be followed by a comprehensive tour across the country.WHEN: 25 December, 9 pm onwardsWHERE: Raasta, Hauz Khas Villagelast_img read more

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first_img Related Content News | Proton Therapy | August 08, 2019 MD Anderson to Expand Proton Therapy Center The University of Texas MD Anderson Cancer Center unveiled plans to expand its Proton Therapy Center during a… read more News | Patient Positioning Radiation Therapy | August 07, 2019 Qfix kVue One Proton Couch Top Validated by Mevion Medical Systems Qfix and Mevion Medical Systems announced that a special version of the kVue One Proton couch top is now both validated… read more The MD Anderson Proton Therapy Center expansion is expected to be completed in 2023. Rendering courtesy of Stantec. 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Data from left and right anterior thalamic radiation (ATR) were averaged. Image courtesy of C. Bouziane et al. Varian TrueBeamSeptember 30, 2013 – IMRIS Inc. and Varian Medical Systems presented data at the American Society for Radiation Oncology (ASTRO) Annual Meeting demonstrating the potential to direct state-of-the-art radiation treatments using diagnostic-quality magnetic resonance (MR) images at each treatment session.In a presentation to radiation oncology clinicians from around the globe, David Jaffray, Ph.D., radiation physicist at the Princess Margaret Cancer Centre and Director of the Techna Institute at the University Health Network (UHN) in Toronto, described a dedicated MR-guided radiation therapy suite that will allow a MR scanner mounted on ceiling rails to perform MR-guided brachytherapy and external beam radiation delivery. Currently being installed at his institution, this combination is a joint development combining IMRIS’ MR imaging with Varian’s TrueBeam system for image-guided radiotherapy and radiosurgery.”Tightly integrating MR imaging with treatment is expected to allow us to increase the accuracy of radiation delivery and pursue research in the emerging field of adaptive radiation therapy — the next level of image-guided radiotherapy that seeks to modify the treatment in response to changes in patient anatomy,” said Jaffray. The team at the Princess Margaret has been performing research on the use of MR in radiation therapy as well as studying how the MR and radiation treatment technologies can be made compatible.”While it is premature to speak to the clinical benefits of the development,” he added, “the technical advantage of enhanced visualization of the tumor and normal tissues at the time of treatment opens many possibilities.” The Princess Margaret team is planning to explore the system’s use in the treatment of prostate, gynecological, and liver cancers, he said.IMRIS and Varian are co-developing the MR-guided radiation therapy system that combines IMRIS’s proprietary MR imaging technology with Varian’s TrueBeam system to enable the use of MR imaging during radiotherapy treatments for cancer. The two companies are collaborating with the team at The Princess Margaret Cancer Centre and UHN’s Techna Institute in Toronto to develop the system, which is not cleared for sale in any jurisdiction at this time.For more information: www.varian.com FacebookTwitterLinkedInPrint分享 Following radiation, the bone marrow shows nearly complete loss of blood cells in mice (left). Mice treated with the PTP-sigma inhibitor displayed rapid recovery of blood cells (purple, right). Credit: UCLA Broad Stem Cell Research Center/Nature Communications News | Brachytherapy Systems | August 14, 2019 Efficacy of Isoray’s Cesium Blu Showcased in Recent Studies August 14, 2019 — Isoray announced a trio of studies recently reported at scientific meetings and published in medica read more Feature | September 30, 2013 Novel MR-guided Radiation Therapy Platform Highlighted at ASTRO last_img read more

Quake rattles Mexico resort

first_imgNo related posts. ACAPULCO, Mexico – A strong earthquake and several aftershocks rattled southern Mexico on Wednesday, collapsing eight homes while forcing schools, hotels and hospitals to evacuate in the Pacific resort of Acapulco.The magnitude-6.0 earthquake swayed buildings as far away as Mexico City, prompting evacuations, but authorities said no damage or injuries were reported in the megalopolis.The temblor struck as people prepared to head to work and school, with an epicenter located 17 kilometers west of the town of San Marcos in the southern state of Guerrero, the National Seismology Center said.The earthquake was followed by eight aftershocks, the strongest reaching magnitude-5.62, some 14 kilometers northeast of Acapulco, where hillside boulders rolled into a street and some hotel facades showed cracks while tourists poured into the streets.Authorities reported damage at five hospitals and three schools but officials did not report injuries, and Guerrero Governor Angel Aguirre said there were no fatalities. Classes were suspended and some 200 patients were evacuated from the hospitals.Mexico City is 440 kilometers north of San Marcos, but the capital can sense distant earthquakes because it lies on muddy soil from drained lakes.A magnitude-8.1 earthquake in 1985 left 3,700 people dead in the capital, according to official figures, though civil groups say more than 20,000 died. Facebook Commentslast_img read more

Chicharrón Fair delicious despite poor attendance

first_img“There aren’t as many people this year,” said one merchant working the fairgrounds yesterday. “Last year, the parking lot was full.” He gestured to the grassy fields that served as a parking area, which were mostly empty.No one could pinpoint exactly why the Chicharrón Fair in Puriscal was so quiet this year, but there were some convincing theories: Organizers had failed to procure the usual carnival rides, one of the big draws for families. Indeed, there was hardly a child to be found. Many of the vendors were not based in Santiago de Puriscal, a town nestled in the mountains west of San José, where the chicharrón is famously well-prepared. Also, the sky was overcast and passing rain showers kept even more people at bay. Even the shack reserved for handling a boa constrictor didn’t attract many customers.However, for the 100 or so people wandering the fairgrounds on Saturday, the fair’s fare was still delicious. Throughout the Spanish-speaking world, chicharrón is generally defined as pork rinds, and it is eaten alone or in various platters, including and Costa Rican chifrijo and Nicaraguan vigorón. But at the Chicharrón Fair, the preparation is much meatier – entire blocks of pork are fried on the spot, mixed with vegetables, pico de gallo, and yucca, then voraciously devoured.“This type is called chilopo,” said Arnoldo Zúñiga, owner of Cheese & Steak Bar in Cartago, as he cut the meat. “I serve it with a special blend of cheeses, Turrialba and some others. It’s delicious.”Despite the absence of toro bullfights and rusty rides, participants managed to find things to do: A group of young men threw around a Frisbee, people browsed the gift stalls, and some people paid a modest ₡20,000 ($40) for a helicopter ride around Puriscal’s breathtaking alpine countryside. When the rain started to fall and patrons headed for cover beneath the chicharrón tents, people started ordering exponentially greater numbers of bottles of Imperial.Maybe it will be better next year. Robert Isenberg/The Tico Times Robert Isenberg/The Tico Times Facebook Comments Robert Isenberg/The Tico Times Robert Isenberg/The Tico Times Robert Isenberg/The Tico Timescenter_img Robert Isenberg/The Tico Times Robert Isenberg/The Tico Times Robert Isenberg/The Tico Times Robert Isenberg/The Tico Times Related posts:It’s Christmas time in the city National Theater announces 2015 season FIA-sco! Arts Festival delayed, afternoon events cancelled in Alajuelita and Acosta Announcing ‘News and Brews,’ a Tico Times eventlast_img read more

Venezuela Indians Germany should return boulder

first_img New high school in Mesa lets students pick career paths “It is not a jasper, it is not stolen, it is not a holy stone _ it’s a pity it needed so many lies to make this conflict and that is why it is very important to get back to the truth,” he said Thursday from Berlin’s central Tiergarten park, where the stone is one of five that make up his “Global Stone” display.Pemon leaders say the stone is sacred because it represents a tribal legend handed down over many generations detailing how a young Pemon man named Kueka fell in love with a girl from another tribe and married her. Kueka’s actions, they say, angered the Pemon deity Makunaima, who opposed inter-tribal marriage. Makunaima punished Kueka and his wife by turning them into stone, thereby immortalizing them as the Pemon’s grandfather and grandmother.Flores and other Pemon Indians at Thursday’s protest referred to the stone in Germany as the tribe’s `grandmother.” Taking the stone away threw off Venezuela’s natural balance, they contend, sparking the deadly floods and mudslides that killed tens of thousands of people in 1999, after the stone was taken.Germany’s ambassador to Caracas, Georg-Clemens Dick, met with the protesters outside the embassy in Caracas and told them he would discuss their demands with government officials in Berlin. Early signs of cataracts in your parents and how to help Meghan McCain to release audiobook on conservatism, family Melchor Flores, a 37-year-old representative of the Pemon who led the march, said, “It’s not just a stone. It’s part of our culture and they must return it.”He said the boulder, known to the Pemon as the “Kueka Stone,” belongs in his community among the grasslands and table-top mountains of the Gran Sabana region. He and others traveled overnight by bus from the region to reach Caracas.In Berlin, artist Wolfgang Kraker von Schwarzenfeld said the protest is the latest controversy over the stone in what has been a 15-year saga. Von Schwarzenfeld removed the boulder from Venezuela’s Canaima National Park in 1997. He said that despite having permission from Venezuelan officials and documentation that the rock was a gift to “the German people,” the initial operation was slowed by local officials who thought it had been stolen.It was then delayed further after the red sandstone was mistaken for semi-precious jasper, which is also found in the area.Von Schwarzenfeld said that Pemon Indians helped him choose it and there was never any question of it being of religious or cultural value to the indigenous community.He suggested that President Hugo Chavez’s government may have contrived the current controversy in order to help secure political support from the Pemon ahead of an Oct. 7 presidential election. He said two YouTube videos have helped spread the idea that the stone is a sacred relic. Top Stories Men’s health affects baby’s health too Reading a written statement, Dick said he has already spoken with officials from Venezuela’s Foreign Ministry, and emphasized that bringing back the boulder would be no simple task.“I ask that you understand the difficulty that an act of this nature entails,” he said.Von Schwarzenfeld said the upside of the current controversy is that it has focused attention on the native people in Venezuela and their rights.“The simplest way of solving the problem is … talking with the indigenous people, saying this was an error and apologize, ask for forgiveness, and also ask for them to please donate the stone to the people of the world,” he said. The stone display, he added, is a “worldwide peace project.”___Associated Press writer David Rising reported from Berlin.(Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)center_img Associated PressCARACAS, Venezuela (AP) – A 35-ton Venezuelan stone that makes up part of a global peace project in Germany is evoking more rage than harmony.The sandstone boulder on display in a Berlin park drew protests in Venezuela Thursday as a group of Pemon Indians demanded the rock, which they view as sacred, be returned to their homeland.More than 100 indigenous Pemon, many of them wearing loincloths, marched to the German Embassy in Caracas, raising ornamental spears and chanting: “Return the stone!” Think Tank analyzes the second round of Democratic debates Sponsored Stories Comments Share How Arizona is preparing the leader of the next generation More Valley freeways to be closed this weekend for improvementslast_img

Birdwatching a big deal in Singapore

first_imgUntapped avitourism industry identified. Image: Malaysia Tourism Board The Malaysian Nature Society (MNS) has declared avitourism to be an untapped, multi-billion dollar industry in Singapore in need of development.The MNS’s Johor branch wants the Singapore Tourism Department to ramp up efforts to grow the unexploited avitourism industry in the state, the New Straits Times reported.The MNS said there was a lack of training courses for tour guides to become competent in the field of nature tourism and claims groups were coming into the state, possibly led by their own guides.“I have received calls from a group of Singaporeans who offered as much as RM16,000 for a local guide who can help them find a particular species of bird,” MNS chairman Vincent Chow said.“Unfortunately, I had to turn them down because I really do not know anyone who can assist them.”The Tourism Department has said there are already licensed local nature guides operating in Singapore but did not reveal the number of guides available.In December 2012 the MNS conducted a joint pilot programme with the Iskandar Regional Development Authority to rope in fishermen in Kampung Sungai Melayu to help in the development of avitourism.“However, the plan later fizzled out… it should be an on-going effort and the relevant government agencies, especially the Tourism Department, should step up efforts to develop avitourism in the state,” Mr Chow said. Source = e-Travel Blackboard: P.Tlast_img read more